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For the management of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. Ask your doctor, nurse, or pharmacist any questions you may have about this medicine. Celebrex is approved for the relief of pain, fever, swelling, and tenderness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. In the treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Celecoxib is used to reduce pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. If you have certain medical conditions. Celebrex is approved for the relief of pain, fever, swelling, and tenderness caused by osteoarthritis, rheumatoid arthritis, acute pain, and nausea versus prescription ibuprofen and naproxen. Celecoxib is used to reduce pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Fluconazole increases the concentration of Celecoxib in the liver.